Mules and human porters have remained the lifeline of the rugged, road less regions of the world from ancient to the modern times. Since the second half of the 20th century, widespread use of mules and human porters has declined in the industrialized and advanced countries, nonetheless even today they extensively operate to transport goods and carry humans in the regions where modern mechanical conveyance are impractical and impossible, such as rugged topography, mountain terrains and forests. Mule, a hybrid of male donkey and female horse is suitably adapted for such regions for their superior strength, tenacity, longevity and endurance. Both mules and human porters, referred to as 'sherpas' in the Himalayan belt are the muscle power and expert navigators in almost each and every expedition. Sherpas on an average can carry approximately 90 percent of their body weight and a mule 20 percent of its body weight or roughly around 90 kg. Their extraordinary capacity to endure adverse climatic conditions, low levels of oxygen and difficulties of high altitudes have often surprised the scientific community and many studies has been conducted to gauge their extraordinary physical capacities and capabilities.